|
KMID : 0358420110540040184
|
|
Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 4 p.184 ~ p.191
|
|
|
THE PROGNOSTIC SIGNIFICANCE OF P16, KI-67, P63, AND CK17 EXPRESSION DETERMINED BY IMMUNOHISTOCHEMICAL STAINING IN CERVICAL INTRAEPITHELIAL NEOPLASIA 1
|
|
Kim Su-Mi
Lee Jung-Uee
Lee Dae-Woo
Kim Min-Jung
Lee Hae-Nam
|
|
|
Abstract
|
|
|
Objective : To evaluate the prognostic signifi cance of p16, Ki-67, p63, and cytokeratin (CK) 17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia (CIN) 1.
Methods: Biopsy tissue samples from 33 patients diagnosed with CIN 1 were stained immunohistochemically for p16, Ki-67, p63, and CK17. The staining results were correlated with the clinical course of the disease.
Results: Seventeen of 18 (94.4%) p16-negative patients experienced regression, and only 1 patient (5.6%) developed persistent disease. Fifteen of the 16 (93.8%) Ki-67-negative patients experienced regression, and 1 patient (6.3%) developed persistent disease. Negative p16 and Ki-67 expression correlated signifi cantly with disease regression (P =0.004 and P =0.017, respectively). Fourteen of 15 (93.3%) patients negative for both p16 and Ki-67 experienced regression, and 1 patient negative for both p16 and Ki-67 (6.7%) developed persistent disease. The expression levels of p63 and CK17 were not signifi cantly associated with disease regression or persistence (P =0.149 and P =0.642, respectively). Ten of the 13 (76.9%) p16-positive patients had a high-risk HPV infection. Highrisk HPV infection was signifi cantly associated with p16 expression (P =0.049).
Conclusion: CIN 1 with p16- or Ki-67-negative immunohistochemical staining was associated with spontaneous disease regression. The p63 and CK17 expression patterns were not related to the behavior of CIN 1.
|
|
|
KEYWORD
|
|
|
p16, Ki-67, p63, CK17
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|